3D printed conformal microfluidics for isolation and profiling of biomarkers from whole organs

Published 2017

Manjot Singh PhD Candidate

Yuxin Tong Ph.D. Candidate, Virginia Tech

Ellen Cesewski Virginia Tech

Alexander P Haring Graduate Student, Virginia Tech

DOI: 10.1039/c7lc00468k

Abstract:

The ability to interface microfluidic devices with native complex biological architectures, such as whole organs, has the potential to shift the paradigm for the study and analysis of biological tissue. Here, we show 3D printing can be used to fabricate bio-inspired conformal microfluidic devices that directly interface with the surface of whole organs. Structured-light scanning techniques enabled the 3D topographical matching of microfluidic device geometry to porcine kidney anatomy. Our studies show molecular species are...

Excerpt:

Molecular cluster analysis (i.e., bio-fingerprinting) of microfluidic biopsy samples was conducted using Raman spectroscopy (Desktop H-PeakSeeker; Agiltron) and methodology established in the literature...

A 4 U laser heterodyne radiometer for methane (CH4) and carbon dioxide (CO2) measurements from an occultation-viewing CubeSat

Published 2017

AJ DiGregorio Science Systems and Applications, Incorporated, NASA Goddard Space Flight Center

DOI: 10.1088/1361-6501/aa5440

Abstract:

We present a design for a 4 U (20 cmƗ 20 cmƗ 10 cm) occultation-viewing laser heterodyne radiometer (LHR) that measures methane (CH 4), carbon dioxide (CO 2) and water vapor (H 2 O) in the limb that is designed for deployment on a 6 U CubeSat. The LHR design collects sunlight that has undergone absorption by the trace gas and mixes it with a distributive feedback (DFB) laser centered at 1640 nm that scans across CO 2, CH 4, and H 2 O absorption features. Upper troposphere/lower stratosphere measurements of these gases...

Excerpt:

Collected sunlight is modulated with a fibre optic switch (CrystaLatch, Agiltron part CLSW- 115231323) at 500 Hz...

A black phosphorus-based tunable Q-switched ytterbium fiber laser

Published 2016

Harith Ahmad University of Malaya

Muhammad Aizi Mat Salim Laser Center, ISI-SIR, Universiti Teknologi Malaysia

DOI: 10.1088/1612-2011/13/9/095103

Abstract:

A compact, passively Q-switched fiber laser with a tunable output is demonstrated. The proposed system uses a short length ytterbium doped fiber to create a very stable and compact optical circuit that uses black phosphorus (BP) as a saturable absorber to generate the desired short pulses. A stable Q-switch pulse train is obtained, with an operational wavelength range from 1056.6ā€“1083.3 nm. Concurrently, a maximum pulse energy and minimum pulse width as well as a repetition rate range of 7.1 nJ, 4 Āµs and 6.0ā€“44.8 kHz...

Excerpt:

The YDF is then joined to a polarization insensitive isolator and subsequently connected to an Agiltron Inc., FOTF-023120323 TBPF. The TBPF serves to filter and stabilize the lasing wavelength...

A new strategy for simple and quick estimation of redox active nickel impurity in pristine SWCNT as nickel hexacyanoferrate by electrochemical technique

Published 2016

Dr. Nandimalla Vishnu Assistant Professor, GITAM University, Hyderabad Campus

Annamalai Senthil Kumar Professor of Chemistry, Nano Bioelectrochemistry Research Lab, Vellore Institute of Technology

DOI: 10.1016/j.snb.2016.07.148

Abstract:

Residual metal impurities in the pristine carbon nanotubes (CNT) have been found to show an exceptional electrochemical and electro-catalytic properties. To quantify the impurities, sophisticated instrumental techniques and time consuming electrochemical methods have been adopted. Herein, we report, a new strategy for simple and quick detection of nickel impurity in pristine single walled carbon nanotube (SWCNT* Ni,* Ni= nickel impurity) as redox active nickel hexacyanoferrate hybrid (SWCNT* Ni-HCF) by potential cycling of the...

Excerpt:

...Agiltron Raman Spectrometer (USA) with 532 nm laser probe instrument was used forRaman spectroscopic analysis...

Analysis and experimental demonstration of an optical switching enabled scalable data center network architecture

Published 2016

Cheng-Yu Ku Professor, Department of Harbor and River Engineering, National Taiwan Ocean University

Chen Kang National University of Singapore

DOI: 10.1016/j.osn.2016.04.002

Abstract:

Optical communication technologies are playing more and more important roles in both intra-and inter-data center networks. Particularly, optical switching network architectures for the inter-rack/pod communications in the data centers have drawn remarkable attention in recent years. By exploiting the high-bandwidth nature and flexible resource allocation capability of optical switching technologies, data center networks (DCNs) may be designed to have high scalability and flexibility, as well as lower cost. Under such design principles...

Excerpt:

To achieve ?s-scale fast optical signal add/drop, Agiltron crystal optical 1 x 2 switches [22] are used, whose switching speed is around 300 ns...

Brillouin filtering of optical combs for narrow linewidth frequency synthesis

Published 2015

Aitor V. Velasco CSIC

DOI: 10.1016/j.optcom.2015.12.012

Abstract:

We report a tunable monochromatic source generation scheme, based on Brillouin filtering of a self-referenced optical frequency comb. The system benefits from the high stability and mode linewidth of the frequency comb, significantly improving the performance of the original laser source used as Brillouin pump. A synthesized frequency with stability under 4Ɨ 10āˆ’ 11 and a linewidth under 75 kHz was experimentally demonstrated for two separate pump lasers in the C-band. The proposed monochromatic source can be tuned with high...

Excerpt:

In order to characterize the ?ltered mode, the synthesized frequency was down-converted with the comb itself in the all-?-ber beat unit. The OFC output was ?ltered with a tunable optical ?ber ?lter (FOTF-025121333 from Agiltron, ranging from 1510 nm to 1580 nm) before beating. Since the SBS ?ltering process pre-serves the original OFC frequency, a frequency shift needs to be induced in the isolated mode for heterodyne characterization...

Characterization and density functional theory optimization of a simultaneous binder (FSG-XO) of two different species exploiting HOMOā€“LUMO levelsĀ ā€¦

Published 2015

DOI: 10.1021/je501013b

Abstract:

A cost-time effective mesoporous ion-exchange material (FSG-XO) has been synthesized by immobilizing xylenol orange on functionalized silica gel. Its spatially separated highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) have been used for the simultaneous sorption of two different metal centers at their respective high and low oxidation states. The characterization of its corresponding nanomaterial,{Si [OSi] p= 2ā€“4 [OH] m= 2ā€“0 x H 2 O} n [āˆ’ Si (CH3) 2ā€“NHā€“C6H4ā€“Nī—» Nā€“XO] 4 has been...

Excerpt:

Raman spectra for the exchanger and its Zn(II) loaded form were studied with Raman System RSL plus.R (model no. 3000 series) (Agiltron 15 [Presidential Way], Woburn, MA 01801, USA) by irradiating the solid mass with a 785 (S) nm laser source at the range of power input 90 mW to 290 mW to achieve the precise resolution...

based microfluidic approach for surface-enhanced Raman spectroscopy and highly reproducible detection of proteins beyond picomolar concentration

Published 2014

Dr. Arindam Saha DST INSPIRE Faculty

Jana, Nikhil Ranjan Chemistry of Nano Materials, Indian Association for the Cultivation of Science

DOI: 10.1021/am508123x

Abstract:

Although microfluidic approach is widely used in various point of care diagnostics, its implementation in surface enhanced Raman spectroscopy (SERS)-based detection is challenging. This is because SERS signal depends on plasmonic nanoparticle aggregation induced generation of stable electromagnetic hot spots and in currently available microfluidic platform this condition is difficult to adapt. Here we show that SERS can be adapted using simple paper based microfluidic system where both the plasmonic...

Excerpt:

SERS measurement was performed using an Agiltron R3000 Raman spectrometer with 785 nm excitation laser having 5 mW laser power and 10 s integration time...

A Versatile Lightā€Switchable Nanorod Memory: Wurtzite ZnO on Perovskite SrTiO3

Published 2013

Ashok Bera Assistant Professor Physics, IIT Jammu

James Lourembam Scientist at Institute of Materials Research and Engineering, A*STAR

DOI: 10.1002/adfm.201300509

Abstract:

Integrating materials with distinct lattice symmetries and dimensions is an effective design strategy toward realizing novel devices with unprecedented functionalities, but many challenges remain in synthesis and device design. Here, a heterojunction memory made of wurtzite ZnO nanorods grown on perovskite Nbā€doped SrTiO3 (NSTO) is reported, the electronic properties of which can be drastically reconfigured by applying a voltage and light. Despite of the distinct lattice structures of ZnO and NSTO, a consistent nature of single...

Excerpt:

Rs and the NSTO substrate, respectively. The current-voltage data were measured using a source meter (Keithley2635). The photoresponse of the ZnO/NSTO diode was measured by illuminating the samples with monochromatic light of wavelength 365 nm and intensity 2.5 W/cm 2 from a solid state UV LED (Agiltron 365A). During the photoresponse measurements, the diode was reverse biased with a voltage of ~ 0.2 V. Supporting Information Supporting Information is available from the Wiley Online Library or from the author. Acknowledgements This work is partially supported by the National...

30-Gb/s optical and electrical test solution for high-volume testing

Published 2013

DOI: 10.1109/test.2013.6651887

Abstract:

To enable high-volume testing of LSIs with high-speed optical and electrical interfaces, we developed a proof-of-concept device of an optical LSI test system for use in mass-production testing. Key technologies include high-density and high-performance optical functional devices and a device interface enabling simultaneous connection of optical and electrical interfaces. Our proposed system, using PLZT thin-film modulators, supports multi-channel optical bit-error-rate (BER) testing of devices with signal rates up to 30 Gb/s with results that...

Excerpt:

Photoreceiver, optical attenuator and switches We used commercially available photorecievers (DSC- R411, Discovery Semiconductor, Inc.) mounted on a sub- module for use as O/E converters. Optical switches (LB series, Agiltron) enable the test functions of the system to be changed without re-connecting the optical and electr i-cal cables. In-line power monitors and attenuators inserted into the system enable the optical power to be controlled and determined during measurement...